On the suitability of Biological structure determination by electron microscopy to Grid Computing

The present contribution describes a potential application of Grid Computing in Bioinformatics. High resolution structure determination of biological specimens is critical in BioSciences to understanding the biological function. The problem is computational intensive. Distributed and Grid Computing are thus becoming essential. This contribution analyzes the use of Grid Computing and its potential benefits in the field of electron microscope tomography of biological specimens. Jose-Jesus Fernandez, Ph.D.: He received his M.Sc. and Ph.D. degrees in Computer Science from the University of Granada, Spain, in 1992 and 1997, respectively. He was a Ph.D. student at the Bio-Computing unit of the National Center for BioTechnology (CNB) from the Spanish National Council of Scientific Research (CSIC), Madrid, Spain. He became an Assistant Professor in 1997 and, subsequently, Associate Professor in 2000 in Computer Architecture at the University of Almeria, Spain. He is a member of the supercomputing-algorithms research group. His research interests include high performance computing (HPC), image processing and tomography. Jose-Roman Bilbao-Castro: He received his M.Sc. degree in Computer Science from the University of Almeria in 2001. He is currently a Ph.D. student at the BioComputing unit of the CNB (CSIC) through a Ph.D. CSIC-grant in conjuction with Dept. Computer Architecture at the University of Malaga (Spain). His current research interestsinclude tomography, HPC and distributed and grid computing. Roberto Marabini, Ph.D.: He received the M.Sc. (1989) and Ph.D. (1995) degrees in Physics from the University Autonoma de Madrid (UAM) and University of Santiago de Compostela, respectively. He was a Ph.D. student at the BioComputing Unit at the CNB (CSIC). He worked at the University of Pennsylvania and the City University of New York from 1998 to 2002. At present he is an Associate Professor at the UAM. His current research interests include inverse problems, image processing and HPC. Jose-Maria Carazo, Ph.D.: He received the M.Sc. degree from the Granada University, Spain, in 1981, and got his Ph.D. in Molecular Biology at the UAM in 1984. He left for Albany, NY, in 1986, coming back to Madrid in 1989 to set up the BioComputing Unit of the CNB (CSIC). He was involved in the Spanish Ministry of Science and Technology as Deputy General Director for Research Planning. Currently, he keeps engaged in his activities at the CNB, the Scientific Park of Madrid and Integromics S.L. Immaculada Garcia, Ph.D.: She received her B.Sc. (1977) and Ph.D. (1986) degrees in Physics from the Complutense University of Madrid and University of Santiago de Compostela, respectively. From 1977 to 1987 she was an Assistant professor at the University of Granada, from 1987 to 1996 Associate professor at the University of Almeria and since 1997 she is a Full Professor and head of Dept. Computer Architecture. She is head of the supercomputing-algorithms research group. Her research interest lies in HPC for irregular problems related to image processing, global optimization and matrix computation.