Activated polymers. II: Synthesis and exchange reactions of biologically active poly(8-acryloxyquinoline)

The monomer 8-acryloxyquinoline (8-AQ) was prepared through the reaction of 8-hydroxyquinoline with either acryloyl chloride or acrylic acid in the presence of triethylamine or N,N-dicyclohexylcarbodiimide, respectively . The resulting monomer was polymerized by free radical polymerization using dimethylformamide (DMF) as a solvent and 2,2^'-azobisisobutyronitrile (AIBN) as an initiator. The reactions of the resulting polymers with hydroxyl and amino compounds have been studied. The polymers were characterized by IR and ¹HNMR spectroscopy. Some of the synthesized polymers were tested for their antimicrobial activity against bacteria and fungi. Generally, all the polymers were effective against the tested microorganisms, but their growth-inhibition effects varied.