| N-甲基-2-哌啶酮的合成研究 |
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| 引用本文： | 王海洋,许浩然,臧娜,王守凯.N-甲基-2-哌啶酮的合成研究[J].精细化工中间体,2010,40(1):52-53,60. |
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| 作者姓名： | 王海洋 许浩然 臧娜 王守凯 |
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| 作者单位： | 中钢集团鞍山热能研究院有限公司,辽宁,鞍山,114044 |
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| 摘 要： | 以2-哌啶酮为原料,硫酸二甲酯为甲基化试剂,在室温下于丙酮溶剂中进行甲基化反应,得到N-甲基-2-哌啶酮。产品纯度﹥99%(GC),收率87.6%,产品结构经1HNMR确认。考察了反应条件对产品收率的影响,并对其反应机理进行探讨。
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| 关 键 词： | 2-哌啶酮 甲基化 硫酸二甲酯 N-甲基-2-哌啶酮 |
Synthesis of N-Methyl-2-piperidone |
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| WANG Hai-yang,XU Hao-ran,ZANG Na,WANG Shou-kai.Synthesis of N-Methyl-2-piperidone[J].Fine Chemical Intermediates,2010,40(1):52-53,60. |
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| Authors: | WANG Hai-yang XU Hao-ran ZANG Na WANG Shou-kai |
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| Affiliation: | (Sinosteel Group Anshan Research Institute of Thermo-energy, Anshan 114044, China) |
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| Abstract: | Methylation of 2-piperidone with dimethyl sulfate （DMS） in acetone at room temperature afforded N- methyl-2-piperidone in 87.6% yield with purity of 99% （GC）. The structure of the product was characterized with 1H NMR. The reaction mechanism and the reaction conditions were discussed. |
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| Keywords: | 2-piperidone methylation dimethyl sulfate N-methyl-2-piperidone |
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