Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export |
| |
Authors: | SS Tseng PL Weaver Y Liu M Hitomi AM Tartakoff TH Chang |
| |
Affiliation: | Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA. |
| |
Abstract: | The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated poly(A)+] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope. This observation raises the possibility that Dbp5p may play a role in unloading or remodeling messenger RNA particles (mRNPs) upon arrival in the cytoplasm and in coupling mRNP export and translation. The functions of Dbp5p are likely to be conserved, since its potential homologues can be found in a variety of eukaryotic cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|