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A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers
Authors:Chen Zhao  Martin M Thuo  Xinyu Liu
Affiliation:1.Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, MD270, Montreal, Quebec, H3A 0C3, Canada;2.Department of Chemistry, University of Massachusetts—Boston, 100 Morrissey Blvd, Boston, MA 02125, USA
Abstract:Abstract

Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and its electrochemical reader will enable the acquisition of high-density, statistically meaningful diagnostic information at the point of care in a rapid and cost-efficient way.
Keywords:paper-based microfluidics  biosensors  electrochemical detection  multiplexing  metabolic markers  disease diagnostics
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