| HPLC法测定阿米三嗪萝巴新片的有关物质 |
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| 引用本文： | 殷学治,韩凤云,计莹.HPLC法测定阿米三嗪萝巴新片的有关物质[J].广东化工,2014(1):166-167. |
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| 作者姓名： | 殷学治 韩凤云 计莹 |
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| 作者单位： | 常州制药厂有限公司,江苏常州213011 |
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| 基金项目： | “重大新药创制”科技重大专项：特殊环境军队特需药品上药集团产学研联盟建设（项目编号：2011ZXJ09301） |
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| 摘 要： | 目的:采用HPLC法测定阿米三嗪萝巴新片的有关物质。方法:采用C18(4.6 mm×250 mm,5μm)色谱柱,流动相为甲醇∶水=85∶15(每1000 mL含二乙胺5μL);流速为1.5 mL/min,检测波长为222 nm。结果:阿米三嗪及萝巴新的线性范围分别为0.15~4.5μg/mL、0.05~1.5μg/mL;平均回收率分别为100.6%、99.3%;结论:本法简便、准确、适合于阿米三嗪萝巴新片有关物质测定。
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| 关 键 词： | 阿米三嗪萝巴新片 HPLC法 有关物质 |
Determination of Almitrine and Raubasine Tablets by HPLC |
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| Yin Xuezhi,Han Fengyun,Ji Ying.Determination of Almitrine and Raubasine Tablets by HPLC[J].Guangdong Chemical Industry,2014(1):166-167. |
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| Authors: | Yin Xuezhi Han Fengyun Ji Ying |
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| Affiliation: | (Changzhou Pharmaceutical Factory, Changzhou 213011, China) |
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| Abstract: | Objective： To establish an HPLC method for quantitative determination of Almitrine and Raubasine Tablets. Methods： The analytical column was C 18 （4.6 mm×250 mm, 5 μm） column. The mobile phase was composed of methanol and water=（85 ： 15）（5 μL diethylamine/1000 mL） at a flow rate of 1.5 mL/min. The wavelength of UV detector was 222 nm. Results： The linear ranges of Almitrine were 0.6-360 μg, Raubasine were 0.2- 120 μg, respectively. The contents of Almitrine and Raubasine were 100.6 %, 99.3 %. Conclusion： This method is sensitive, repeatable to determine the content of Almitrine and Raubasine Tablets. |
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| Keywords: | Almitrine and Raubasine HPLC method Content Determination |
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