| 中药提取物中黄嘌呤氧化酶抑制剂的筛选 |
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| 引用本文： | 黎莉,戴立珍,杨靖,方继德.中药提取物中黄嘌呤氧化酶抑制剂的筛选[J].武汉化工学院学报,2010(3):44-46. |
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| 作者姓名： | 黎莉 戴立珍 杨靖 方继德 |
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| 作者单位： | 武汉工程大学化工与制药学院绿色化工过程教育部重点实验室; |
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| 摘 要： | 用带有酶动力学分析软件的紫外分光光度计，测定多种中药提取物对黄嘌呤氧化酶的抑制活性．测定波长为294nm，黄嘌呤氧化酶1．14units／mL．筛选在体外能抑制黄嘌呤氧化酶活性的中药提取物，并比较了它们的抑制活性．结果表明枳棋子乙醇提取物、高良姜乙醇提取物和葛花乙酸乙酯提取物对黄瞟呤氧化酶显示出较强的抑制活性；说明上述3种提取物是抑制黄嘌呤氧化酶的活性部位，可进一步分离纯化得到有效化合物．
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| 关 键 词： | 枳棋子 高良姜 葛花 黄嘌呤氧化酶 动力学分光光度法 |
Study on Xanthine Oxidase inhibitory activity of the extracts from Chinese Herbal Medicines |
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| LI Li,DAI Li-zhen,YANG Jing,FANG Ji-de.Study on Xanthine Oxidase inhibitory activity of the extracts from Chinese Herbal Medicines[J].Journal of Wuhan Institute of Chemical Technology,2010(3):44-46. |
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| Authors: | LI Li DAI Li-zhen YANG Jing FANG Ji-de |
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| Affiliation: | LI Li,DAI Li-zhen,YANG Jing,FANG Ji-de(School of Chemical Engineering & Pharmacy,Wuhan Institute of Technology,Key Laboratory for Green Chemical Process of Ministry of Education,Wuhan 430074,China) |
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| Abstract: | Xanthine oxidase inhibitory activity of multiple herbal medicine samples were determined by UV spectrophotometer with enzyme kinetics analysis software,wavelength 294 nm,xanthine oxidase 1.14 units/mL.The extracts of Chinese herbal medicines were screened,which can inhibit the activity of xanthine oxidase in vitro,and their inhibitory activity were compared.The resules were that ethanol extracts of Semen Hoveniae,ethanol extracts of Rhizoma Alpiniae officinarum and ethylacetate extract of Flos Pueraiae show... |
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| Keywords: | Semen Hoveniae Rhizoma Alpiniae officinarum Flos Pueraiae xanthine oxidase kinetic spectrophotometry |
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