Polypyridyl CoII-Curcumin Complexes as Photoactivated Anticancer and Antibacterial Agents |
| |
Authors: | Ashish Kumar Yadav Virendra Singh Rajesh Kushwaha Dr Dependu Dolui Rohit Rai Dr Prodyut Dhar Dr Arnab Dutta Dr Biplob Koch Dr Samya Banerjee |
| |
Affiliation: | 1. Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, 221005 India;2. Department of Zoology, Institution of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005 India;3. Department of chemistry, Indian Institute of Technology Bombay, Powai, Maharashtra, 400076 India;4. School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, 221005 India |
| |
Abstract: | Four new CoII complexes, Co(bpy)2(acac)]Cl ( 1 ), Co(phen)2(acac)]Cl ( 2 ), Co(bpy)2(cur)]Cl ( 3 ), Co(phen)2(cur)]Cl ( 4 ), where bpy=2,2’-bipyridine ( 1 and 3 ), phen=1,10-phenanthroline ( 2 and 4 ), acac = acetylacetonate ( 1 and 2 ), cur=curcumin monoanion ( 3 and 4 ) have been designed, synthesized and fully characterized. The X-ray crystal structures of 1 and 2 indicated that the CoN4O2 core has a distorted octahedral geometry. The photoactivity of these complexes was tuned by varying the π conjugation in the ligands. Curcumin complexes 3 and 4 had an intense absorption band near 435 nm, which made them useful as visible-light photodynamic therapy agents; they also showed fluorescence with λem≈565 nm. This fluorescence was useful for studying their intracellular uptake and localization in MCF-7 breast cancer cells. The acetylacetonate complexes ( 1 and 2 ) were used as control complexes to understand the role of curcumin. The white-light-triggered anticancer profiles of the cytosol targeting complexes 3 and 4 were investigated in detail. These non-dark toxic complexes displayed significant apoptotic photo-cytotoxicity (under visible light) against MCF-7 cells through ROS generation. The control complexes 1 and 2 did not induce significant cell death in the light or dark. Interestingly, 1-4 produced a remarkable antibacterial response upon light exposure. Overall, the reported results here can increase the boundary of the CoII-based anticancer and antibacterial drug development. |
| |
Keywords: | anticancer agents antimicrobial agents CoII complexes curcumin-based complexes photosensitizers |
|
|