The conversion of phosphatidylethanolamine into phosphatidylcholine labeled in the choline group using methyl lodide, 18-crown-6 and potassium carbonate |
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| Authors: | K. M. Patel J. D. Morrisett J. T. Sparrow |
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| Affiliation: | (1) Department of Medicine, Baylor College of Medicine and The Methodist Hospital, 77030 Houston, Texas;(2) Present address: American Heart Association, USA |
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| Abstract: | A chemical method for the conversion of phosphatidylethanolamine into phosphatidylcholine is described. Methyl iodide in the presence 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane) and potassium carbonate in benzene is used to alkylate phosphatidylethanolamine in 2.5 hr at 37 C to give an isotopically enriched phosphatidylcholine. The product is purified conventionally and is obtained in 75% yield. |
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