In Vitro evaluation and dissipative particle dynamics simulation of PLGA‐PEG‐PLGA |
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| Authors: | Yang Cao Bochu Wang Lichun Yang Yazhou Wang Gurinder K. Singh |
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| Affiliation: | 1. Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China |
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| Abstract: | Thermosensitive PLGA‐PEG‐PLGA triblock copolymers have great potential to be utilized in intravitreal injection. It is important to understand the mechanisms of selfassembled behaviors of triblock copolymers. In this study, dissipative particle dynamics simulation is used to explore the phase behaviors and morphologies of the copolymers. Phase transition, complex viscosities, swelling characteristics, and degradation behavior were investigated. The results suggested that the structures of copolymers were greatly affected by polymer concentration. Phase behavior of copolymers can be modified by alternating polymer size distribution. It exhibited that particle diameter was temperature dependence and polymer concentration can increase micelles numbers in solutions. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41280. |
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| Keywords: | nanostructured polymers phase behavior rheology ring‐opening polymerization thermal properties |
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