Salt and pH sensitive semi‐interpenetrating polyelectrolyte hydrogels poly(HEMA‐co‐METAC)/PEG and its BSA adsorption behavior |
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Authors: | Yan‐Yan Hu Jing Zhang Qi‐Chen Fang Dong‐Mei Jiang Chu‐Cheng Lin Yi Zeng Ji‐Sen Jiang |
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Affiliation: | 1. Department of Physics, Center for Functional Nanomateriels and Devices, East China Normal University, Shanghai, People's Republic of China;2. Shanghai Key Laboratory of Diabeties Mellitus, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, People's Republic of China;3. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China;4. Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, People's Republic of China |
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Abstract: | A novel semi‐interpenetrating poly(2‐hydroxyethyl methacrylate) (pHEMA) based polyelectrolyte hydrogel p(HEMA‐co‐METAC)/PEG] was prepared by copolymerizing HEMA with the cationic monomer 2‐methacryloyloxyethyltrimethyl ammonium chloride (METAC) in the presence of polyethylene glycol (PEG) with different content and molecular weight (MW 4000 and 400). The chemical structure of the gels was confirmed by FT‐IR spectroscopy, morphology study was performed by scanning electron microscope (SEM), thermal stability was revealed by thermogravimetric analysis (TGA), and the mechanical properties were determined by electronic universal testing machine. Swelling studies showed introduction of cationic monomer METAC led to high water content, and the obvious salt and pH sensitive properties were observed which proved the smart behavior of the semi‐interpenetrating polymer networks (IPNs) gels. In addition, the effect of temperature and some important biological solution on swelling behavior were reported. Cytotoxicity test demonstrated that synthesized gels owned satisfactory cytocompatibility and were convenient for the application as biomaterials. Finally, the weak bovine serum albumin (BSA) adsorption on semi‐IPNs by introducing METAC and controlling the content of PEG in gels demonstrated that they were of good protein resistance effect in biomedical applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41537. |
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Keywords: | biocompatibility proteins stimuli‐sensitive polymers swelling |
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