载药淀粉微球合成条件的研究

为了解决靶向给药的难题,以马铃薯淀粉为原料,选用新型的交联剂、乳化剂,以吸附量为指标,进行正交试验。结果表明,载药淀粉微球的最佳合成条件为:淀粉7g,加水65ml,搅拌成糊状,用NaOH调节pH=8～9,于80℃下活化0.5h。在三口烧瓶中加入0.4g乳化剂,加入100ml植物油,60℃下使乳化剂溶解,加入淀粉,搅拌。用显微镜观察淀粉的分散性,当达到要求后,加入1.2g交联剂、0.6g引发剂,于55℃下反应3h。该产品有效的解决了药物的靶向性,大大提高了药物的疗效,降低了药物对人体的副作用。

Study on synthesis of holding-drug-starch microsphere

To solve the problem of targeting direction of medicine, potato starch as the raw material and choose new style cross linking agent and emulgent.The orthogonal experiment is made with the adsorption as the target.The results showed that the optimum conditions for synthesizing holding drug starch microsphere were as follows: starch 7 g , add the water 65 ml and agitate until to paste , regulate the pH=8～9 with sodium hydroxide , activate 0.5 h at 80 ℃. Solve 0.4 g emulgent with 100 ml plant oil at 60 ℃ in the three mouth flask, then add starch and agitate,observe the starch dispersion through the microscope, when it attains to requirement ,add 1.2 g cross linking agent,0.6 g initiator,reaction for 3 h at 55 ℃. The product effectively solved the problem of targeting direction of medicine, and increased the healing effects of the medicine while decreasing the reverse effects for human being.