Preparation and characterization of chitosan-poly(acrylic acid) polymer magnetic microspheres |
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Authors: | Yan Wu Changchun Wang Shoukuan Fu |
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Affiliation: | Key Laboratory of Macromolecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, People's Republic of China |
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Abstract: | A modified method to prepare chitosan-poly(acrylic acid)(CS-PAA) polymer magnetic microspheres was reported in this paper. First, via self-assembly of positively charged CS and negatively charged Fe3O4 nanoparticles, magnetic CS cores with a large amount of Fe3O4 nanoparticles were successfully prepared. Subsequently, the AA monomers were polymerized on the magetic CS cores based on the reaction system of water-soluble polymer-monomer pairs. These polymer magnetic microspheres had a high Fe3O4 loading content, and showed unique pH-dependent behaviors on the size and zeta potential. From the magnetometer measurements data, the CS-PAA polymer magnetic microspheres also had superparamagnetic property as well as fast magnetic response. A continuous release of the entrapped ammonium glycyrrhizinate in such polymer magnetic microspheres occurred, which confirmed the potential applications of these microspheres for the targeted delivery of drugs. |
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Keywords: | Chitosan-poly(acrylic acid) Polymer magnetic microspheres Controlled drug delivery |
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