医用NiTi合金表面改性的研究进展

近等原子比NiTi合金具有独特的力学性能,如形状记忆效应、超弹性和高阻尼效应,已成为一种新型的整形外科植入材料.但是,镍元素在生理条件下可能溶出,诱发毒性和炎性反应,限制了其在临床的广泛应用.分类介绍了几种可行的表面改性方法,均能有效地抑制镍离子的溶出,改善NiTi合金的抗腐蚀性和生物相容性,包括表面惰性涂层化、表面氧化、表面活性化和表面接枝大分子等.

Progress in Research on Surface Modification of Biomedical Nickel-Titanium Alloys

Nearly equiatomic nickel-titanium alloy has emerged as a new type of orthopedic implants due to its unique mechanical properties of shape memory effect, super-elasticity and high damping capacity. However, a critical concern is that nickel may be release from the implants in physiological environment and nickel is responsible for toxic and allergic responses, limiting its wide use in clinical applications. In this paper, several feasible surface modification methods restraining nickel dissolved effectively and improving in corrosion resistance and biocompatibility are delicately classified and analyzed, which include surface inertia coatings treatment, surface oxidation treatment, surface bioactive treatment and surface immobilizing macromolecules.