Development of 153Sm-bleomycin as a possible therapeutic complex |
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Authors: | BAHRAMI-SAMANI Ali GHANNADI-MARAGHEH Mohammad JALILIAN Amir Reza YOUSEFNIA Hassan MORADKHANI Sedighch BOLOURINOVIN Fatemeh |
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Affiliation: | [1]Faculty of Nuclear Engmeermg and Phystcs, Amtr Kabtr University, Tehran, Iran [2]Radiopharmaceutical Research and Development Laboratories, Nuclear Science and Technology Research Institute, Tehran, Iran |
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Abstract: | Due to interesting therapeutic properties of 153Sm and antineoplastic antibiotic,bleomycin(BLM),153Sm-bleomycin(153Sm-BLM)was developed as a possible therapeutic compound using 153SMCl3 and BLM.The 153SMCl3 was obtained by thermal neutron flux(5×1013 n·cm-2·s-1)of an enriched 152Sm2O3 sample,dissolved in acidic media.Under optimized conditions(room temperature,45 min,0.1mg bleomycin for 740-3700 MBq 153SMCl3)a radiochemical purity over 98 % was obtained shown by HPLC(Specific activity=55 TBq/mM).The 153SMCl3 and 153Sm-BLM were administered into wild-type rats up to 96 h followed by biodistribution.The SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound.The 153Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality,and stability suitable for future therapeutic studies. |
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Keywords: | Bleomycin Sm-153 Biodistribution Radiolabeling |
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