| 药用植物中乙酰胆碱酯酶抑制剂研究进展 |
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| 引用本文： | 杨建红,陶媛媛,张云梅,陈业高.药用植物中乙酰胆碱酯酶抑制剂研究进展[J].云南化工,2006,33(6):78-82. |
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| 作者姓名： | 杨建红 陶媛媛 张云梅 陈业高 |
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| 作者单位： | 1. 云南师范大学,化学系,云南,昆明,650092
2. 昆明冶金高等专科学校,环境与市政工程系,云南,昆明,650033 |
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| 摘 要： | 众多学者对植物中治疗老年性痴呆的化学成分进行了大量研究,发现了一些具有乙酰胆碱酯酶抑制的活性成分,主要为生物碱、萜、黄酮和香豆素等结构类型的化合物。其中生物碱类乙酰胆碱酯酶抑制剂如石杉碱甲、加兰他敏等因活性高、选择性强而受到广泛的关注。进一步开展药用植物中乙酰胆碱酯酶抑制活性成分研究,寻找新作用机制的化合物对发现新的治疗老年性痴呆的药用成分有重要意义。
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| 关 键 词： | 乙酰胆碱酯酶 抑制剂 老年性痴呆 药用植物 |
| 文章编号： | 1004-275X（2006）06-0078-05 |
| 收稿时间： | 2006-07-25 |
| 修稿时间： | 2006年7月25日 |
Advance on Acetylcholinesterase Inhibitors from Medicinal Plants |
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| YANG Jian-hong,TAO Yuan-yuan,ZHANG Yun-mei,CHEN Ye-gao.Advance on Acetylcholinesterase Inhibitors from Medicinal Plants[J].Yunnan Chemical Technology,2006,33(6):78-82. |
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| Authors: | YANG Jian-hong TAO Yuan-yuan ZHANG Yun-mei CHEN Ye-gao |
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| Affiliation: | 1. Department of Chemistry, Yunnan Normal University, Kunming 650092, China; 2. Department of Environmental and Municipal Engineering, Kunming Metallurgy School, Kunming 650033, China |
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| Abstract: | Plant derived acetylcholinesterase inhibitors including alkaloids, terponoids, flavonoids and coumarins were found from medicinal plants. Alkaloids such as huperzine A and galanthamine had high activity and selectivity, which drawn much attention. Studies on new acctylcholinesterase inhihitors from plants would have important significance to the finding of new bioactive compounds and drug development. |
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| Keywords: | acetylcholinesterase inhibitors Alzeimer disease medicinal plants |
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