膳食纤维干预炎症性肠病研究进展

炎症性肠病（Inflammatory bowel disease，IBD）是一种慢性、反复发作、久治难愈的胃肠道炎症性疾病，通常伴随着炎性细胞浸润及肠粘膜受损，具有一定的癌变风险。大量研究表明，膳食纤维（Dietary fiber，DF）作为一种益生元，在改善肠道菌群结构、强化肠道屏障功能、缓解肠道炎症等方面功效显著，具有多重营养及保健功能，在干预IBD方面表现出巨大的潜力，但其中的作用机制尚未阐明。此外，DFs由于水溶性不同可分为可溶性膳食纤维（Soluble dietary fiber，SDF）和不溶性膳食纤维（Insoluble dietary fiber，IDF），二者特性不同，对IBD的作用效果也不尽相同。因此，本文就SDF和IDF防治IBD的基本原理、现有证据及其作用机制进行综述，综合分析了IBD的DFs干预治疗策略，为DFs的深入研究和开发应用提供参考。

Research Progress of Dietary Fiber Intervention in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic, recurrent, and refractory inflammatory disease of the gastrointestinal tract, accompanied by inflammatory cell infiltration and damage to the intestinal mucosa, with a certain risk of cancer. A large number of studies have shown that dietary fiber, as a prebiotic, has significant effects in improving intestinal flora structure, strengthening intestinal barrier function, alleviating intestinal inflammation and other aspects, with multiple nutritional and health functions, showing great potential in the intervention of IBD, but the mechanism of action remains unclear. In addition, DFs can be classified into soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) according to their water solubility, which have different characteristics and effects on IBD. Therefore, this paper reviews the basic principles, existing evidence and mechanism of SDF and IDF in the prevention and treatment of IBD, and comprehensively analyzes DFs intervention strategies for IBD, so as to provide reference for further research, development and application of DFs.