结合态多酚改善肠道氧化应激与肠道屏障的研究进展

食品中富含种类丰富的酚类化合物，并且酚类化合物是天然的抗氧化剂和重要的功能因子。结合态多酚是酚类化合物的一种存在形式，其存在于提取过游离态多酚的残渣中，通过酯键、糖苷键、醚苷键等形式与其他物质相结合。肠道作为人体免疫防御的最前线，易遭受外源性和代谢性氧自由基损伤，诱发肠道氧化应激。肠道氧化应激会通过多种途径破坏肠上皮细胞间的紧密连接状态，导致肠上皮屏障功能受损和肠道通透性增加，进而诱发各种疾病。结合态多酚作为一种天然的抗氧化剂，在肠道中具有较完整的结构和稳定的活性，并通过调节免疫功能，以及影响炎症因子、抗氧化酶和屏障蛋白的表达，对肠道氧化应激以及肠道屏障功能的受损均有着改善作用。

Research Progress of Bound Polyphenols in Improving Intestinal Oxidative Stress and Intestinal Barrier

Food is abundant in phenolic compounds and phenols are perceived as a rich source of natural antioxidants and vital functional factors. Bound polyphenols are a form of phenolic compounds that exist in the residue from which free polyphenols have been extracted and are combined with other substances through ester bonds, glycosidic bonds, ether glycosidic bonds, etc. As the forefront of human immune defense, the intestine is prone to exogenous and metabolic oxygen radical damage, which triggers intestinal oxidative stress. Intestinal oxidative stress can disrupt the tight junctions between intestinal epithelial cells through various pathways, leading to intestinal epithelial barrier functional impairment and increasing intestinal permeability, which can induce various diseases. Bound polyphenols, as a natural antioxidant, have structural integrity and activity stability in the intestine. These components feature an ameliorative effect on intestinal oxidative stress as well as impaired intestinal barrier function by modulating immune function and regulating the expression of inflammatory factors, antioxidant enzymes and barrier proteins.