降糖肽的制备、生物学效应及其构效关系研究进展

糖尿病是一个严重的全球性健康问题，其发病率近年来呈上升态势。目前证实已有多种药物可有效治疗糖尿病，但多数药物存在毒副作用。因此，研发出安全有效的降糖药物已经成为全世界关注的焦点。降糖肽具有降血糖作用且毒副作用较小，在功能食品和药品领域具有开发价值，应用前景广阔。本文综述了近年来对降糖肽的制备、生物学效应以及构效关系等方面的研究进展，并对降糖肽的研究进行了展望，以期为降糖肽的开发利用及相关产品的深加工提供参考。

Advances in Preparation,Biological Effect and Structure-activity Relationship of Hypoglycemic Peptides

Diabetes is a serious global health problem, and its incidence rate has been increasing in recent years. Many drugs have been proven effective in the treatment of diabetes mellitus, but most of them have toxic side effects. Therefore, the development of safe and effective hypoglycemic drugs have drawn increasingly more attention around the world. Hypoglycemic peptides has the hypoglycemic effect and has little side effects, and has the research value in the field of functional food and drugs, and has a broad application prospect. In this paper, the preparation, biological effect and structure-activity relationship of hypoglycemic peptides in recent years are reviewed, and the research prospect of hypoglycemic peptides is looked forward, in order to provide reference for the development and utilization of hypoglycemic peptides and the further processing of related products.