| 气质联用测定雷贝拉唑钠中三氯甲烷残留 |
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| 引用本文： | 徐英,孟宏伟,黄桂华,韩勇. 气质联用测定雷贝拉唑钠中三氯甲烷残留[J]. 山东化工, 2010, 39(2): 31-32 |
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| 作者姓名： | 徐英 孟宏伟 黄桂华 韩勇 |
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| 作者单位： | 1. 山东大学药学院,山东,济南,250100;山东新华制药研究院,山东,淄博,255005
2. 山东大学药学院,山东,济南,250100 |
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| 摘 要： | 采用GC-MS法测定原料药中三氯甲烷溶剂残留。样品和对照以乙醇为溶剂,HP-5ms色谱柱分离,质谱检测器选择离子检测测定了雷贝拉唑钠中三氯甲烷残留。三氯甲烷在方法考察浓度范围内具有良好线性,回归方程A=1190.5C-232.45(C为μg/mL),r=0.9998,平均回收率100.1%,精密度RSD=0.21%。该方法灵敏、准确,可以用于雷贝拉唑钠中三氯甲烷残留量检测。
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| 关 键 词： | 雷贝拉唑钠 三氯甲烷 气质联用 |
Determination of Chloroform in Rabeprazole Sodium by GC-MS |
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| XU Ying,MENG Hong - wei,HUANG Gui - hua,HAN Yong. Determination of Chloroform in Rabeprazole Sodium by GC-MS[J]. Shandong Chemical Industry, 2010, 39(2): 31-32 |
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| Authors: | XU Ying MENG Hong - wei HUANG Gui - hua HAN Yong |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China; 2. Institute of Shandong Xinhua Pharmaceutical Limited Company,Zibo 255005,China) |
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| Abstract: | A method for detemination of chloroform in rabeprazole sodium by GC - MS was reported. Samplesand reference were dissolved in ethanol. A HP - 5ms quartz capillary column was used. The chloroform was analyzed by GC - MS with selected ion monitoring mode. Method have good linearity, and the regression equation was A -- 1190.5C （μg/mL） - 232.45, r = 0. 9998, average recovery was 100. 1%, RSD = 0.21%. Method was sensitive and exactive, could be used in the detemination of chloroform in rabeprazole sodium |
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| Keywords: | rabeprazole sodium chloroform GC - MS |
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