ND-2001 suppresses lung metastasis of human renal cancer cells in athymic mice |
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| Authors: | Y Kuramitsu J Hamada T Tsuruoka K Morikawa S Naito H Kobayashi M Hosokawa |
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| Affiliation: | Laboratories of Pathology, Hokkaido University School of Medicine, Sapporo, Japan. |
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| Abstract: | Explants of highly metastatic human renal cell carcinoma SN12Cpm6 cells in athymic mice were treated with sodium D-glucaro-delta-lactam (sodium 5-amino-5-deoxy-D-glucosaccharic acid-delta-lactam; ND-2001). ND-2001 (50 micrograms/ml) caused 78% inhibition of lung metastasis of SN12Cpm6 cells (two of five animals remaining metastasis free). The in vitro tumor cell invasion assay showed that ND-2001 (100 micrograms/ml) suppressed the invasive activity of SN12Cpm6 cells to Matrigel matrix at an inhibition rate of 72%. These results suggest that ND-2001 may be a new anti-metastatic drug against human cancer cells. |
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