Matrix metalloproteinase-2 inhibition and Zn2+-chelating activities of pyoverdine-type siderophores |
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| Authors: | Shinozaki-Tajiri Yukiko Akutsu-Shigeno Yukie Nakajima-Kambe Toshiaki Inomata Shinji Nomura Nobuhiko Uchiyama Hiroo |
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| Affiliation: | Institute of Applied Biochemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan. |
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| Abstract: | Pyoverdine-type siderophores from fluorescent Pseudomonas species were purified by Zn2+-chelate chromatography, and their matrix metalloproteinase-2 (MMP-2) inhibition and metal-ion-chelating activities were studied. Structurally different pyoverdines showed different MMP-2 inhibition activities, and the inhibition activity was correlated with Zn2+-chelating activity. The IC50 value of a pyoverdine ((P113A1)-2, MW 1187) for MMP-2 was 0.27 microg/ml (0.23 microM). |
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