| 抗菌肽异源表达的研究进展 |
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| 引用本文： | 刘辉, 张兰威, 易华西, 韩雪. 抗菌肽异源表达的研究进展[J]. 食品工业科技, 2016, (12): 380-384. DOI: 10.13386/j.issn1002-0306.2016.12.064 |
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| 作者姓名： | 刘辉 张兰威 易华西 韩雪 |
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| 作者单位： | 1.哈尔滨工业大学化学工程与技术学院 |
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| 摘 要： | 抗菌肽是一种小肽类物质,可以抑制多种细菌、真菌、病毒以及抗生素抗性细菌。但是抗菌肽产量低提取工艺繁琐,制约其工业化生产和科学研究。异源表达技术为提高抗菌肽产量提供了十分有效的途径。目前抗菌肽异源表达系统,主要包括大肠杆菌和酵母菌表达系统。本文主要综述了大肠杆菌和酵母菌表达系统的优缺点以及发展方向,为利用生物技术方法提高抗菌肽产量提供理论依据和技术支持。
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| 关 键 词： | 抗菌肽 异源表达 大肠杆菌 酵母菌 |
| 收稿时间： | 2015-11-30 |
Heterologous expression systems for recombinant production of antimicrobial peptides |
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| LIU Hui, ZHANG Lan- wei, YI Hua-xi, HAN Xue. Heterologous expression systems for recombinant production of antimicrobial peptides[J]. Science and Technology of Food Industry, 2016, (12): 380-384. DOI: 10.13386/j.issn1002-0306.2016.12.064 |
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| Authors: | LIU Hui ZHANG Lan- wei YI Hua-xi HAN Xue |
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| Affiliation: | 1.School of Chemcial Engneering and Technology,Harbin Institute of Technology |
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| Abstract: | Antimicrobial peptide( AMP) is a kind of small peptides. AMP has the inhibition of various bacteria,fungi and viruses. However,the low quantity of peptides and complex purification process are still a remarkable bottleneck for scientific and industrial research development. Heterologous expression technology provides a effective way to improve the production of AMP. The main heterologous systems currently used for AMP production,including bacteria,yeast. This review described the heterologous expression system of antimicrobial peptide,compared the advantages and disadvantages in each expression system.It was designed to provide the basis of theoretical and technical support for the mass production of antimicrobial peptides by biotechnological tools. |
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| Keywords: | antimicrobial peptides heterologous expression E.coli yeast |
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