火麻仁油—藻油复配剂对混合型高脂血症大鼠的降脂及抗氧化作用

探讨火麻仁油—藻油复配剂对混合型高脂血症大鼠的降脂作用及抗氧化作用。将50只大鼠随机分为5组,每组10只,分别为空白对照组、模型对照组和复配剂低剂量组、中剂量组及高剂量组。高脂饲料喂养并给予相应药物灌胃后,测大鼠体重、睾脂肪垫重、肾周脂肪垫重、脂体比,检测血脂水平、血清的丙二醛(MAD)、谷胱甘肽(GSH)含量及过氧化超氧化物歧化酶(SOD)的活性。结果表明:模型组大鼠与正常组比较,体重、睾脂肪垫重、肾周脂肪垫重、脂体比显著增加,TG、TC含量显著升高,HDL-C显著降低,MDA显著升高,SOD、GSH、GSH-Px显著降低(P0.01或P0.05)。与模型组比较,火麻仁油藻油高、中、低剂量组大鼠体重、睾脂肪垫重、肾周脂肪垫重、脂体比显著降低,MDA含量显著降低,SOD、GSH、GSH-Px含量显著升高(P0.01或P0.05)。火麻仁油—藻油复配剂具有调节血脂和抗氧化作用。

Effect of hemp seed and algae oils preparation on blood lipid-lowering and antioxidant activities for mixed hyperlipidemia rats

Objective: The effects of hemp seed and algae oils preparation on blood lipid-lowering and antioxidant activity of mixed hyperlipidemia rats were investigated in this study. 50 rats were randomly divided into 5 groups, i.e., the blank control group, model control group, hemp seed oil and algal oil preparation low dose group (170 mg/kg), medium dose group (340 mg/kg) and high dose group (510 mg/kg). Then their weights of , testis fat pad and perirenal fat pad, fat body ratio, and the activities of malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) were measured after feeding high fat diet and corresponding drugs. The results indicated that the weights of gain, and testis and perirenal fat pads, fat body ratio, TG, TC and MDA of model control group rats increased significantly, however, the activities of GSH, GSH-Px and SOD, and the high-density lipoprotein cholesterol (HDL-C) reduced significantly (P < 0.05, P < 0.01), compared to the blank group. Moreover, in the high dose and low dose group of hemp seed oil and algae oil preparation, rats weight, weights of testis and perirenal fat pads, body fat ratio decreased significantly, and the content of MDA decreased significantly, while the activities of SOD, GSH and GSH PX significantly increased (P < 0.05 or P < 0.05), compared to the model control group. In conclusion, our results confirmed that the hemp seed and algae oils preparation could regulate blood lipid and possessed strong antioxidant activities.