RK-2: a novel rabbit kidney defensin and its implications for renal host defense |
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Authors: | ER Wu R Daniel A Bateman |
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Affiliation: | Royal Victoria Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada. |
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Abstract: | Defensins are endogenous antimicrobial peptides. We demonstrated recently the existence of RK-1, a defensin-like peptide in rabbit kidneys. Defining the renal-defensin system is an essential step toward understanding how the kidney responds to infection. Here, using a combination of high-performance liquid chromatography, matrix-assisted laser desorption time-of-flight mass spectrometry, amino acid compositional analysis, and microsequence analysis, we show that the rabbit kidney contains a novel alpha-defensin-like peptide, RK-2. This work establishes the existence of a new subfamily of alpha-defensins in the kidney. |
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