Effects of mycotoxins on mixed-function oxidase and adenosine triphosphatase systems in neonatal rats. I. aflatoxin B1/rubratoxin B |
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| Authors: | T D Phillips M Y Siraj A W Hayes |
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| Affiliation: | 1. Division of Cardiology, Steward St Elizabeth’s Medical Center, Boston, Massachusetts;2. Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts;3. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts;4. CardiacRMS, Saratoga Springs, New York;1. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, I.R, Iran;2. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;3. Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;4. Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran;4. Microbiology, Immunology, Infectious Diseases, and Transplants (MIMIT), University of Rome “Tor Vergata”, Rome, Italy |
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| Abstract: | The effects of aflatoxin B1 and/or rubratoxin B on hepatic monooxygenase and hepatic, brain and renal ATPase activities were examined in neonatal rats exposed to a single treatment of one or both toxins. Animals received orally 0·4 mg aflatoxin B1/kg, 2 mg rubratoxin B/kg or the same doses of aflatoxin B1 and rubratoxin B in combination, within 24 hr of birth, and were killed 12 days later. Given alone, rubratoxin B caused a statistically significant decrease in cytochrome P-450 content. Hepatic and renal oligomycin-sensitive ATPase activity was depressed by the aflatoxin B1 and rubratoxin B combination but this effect appeared to be the result of the aflatoxin treatment. The only interaction observed after exposure of pups to the mycotoxin combination was a tendency towards a decrease in NADPH-dependent dehydrogenase. |
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