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Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorrhage of complex origin in endovascular surgery of children |
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| Authors: | Daniel Horák Ilya E Galibin Arnold A Adamyan Alexander V Sitnikov Vasilii N Dan Mariya I Titova Vladimir V Shafranov Yurii F Isakov Klara Z Gumargalieva Tatyana I Vinokurova |
| Affiliation: | (1) Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, Prague 6, 162 06, Czech Republic;(2) Filatov Children City Hospital No. 13, Sadovaya Kudrinskaya 15, Moscow, 123 001, Russia;(3) Vishnevskii Institute of Surgery, Russian Academy of Medical Sciences, Bolshaya Serpukhovskaya 27, Moscow, 115 093, Russia;(4) Institute of Chemical Physics, Russian Academy of Sciences, Kosygina 4, Moscow, 119 991, Russia |
| Abstract: | Poly(2-hydroxyethyl methacrylate) (PHEMA) embolization particles with enhanced haemostatic properties were prepared by bulk or suspension polymerisation of 2-hydroxyethyl methacrylate (HEMA) followed by particle soaking in ethamsylate solution. The particles accelerated thrombus formation as evidenced by blood analysis of rabbits with implanted emboli. Usefulness of both spherical and cylindrical PHEMA particles with enhanced haemostatic effect was demonstrated on the embolization of arterial anastomosis, fistulas of the lower extremity and abdominal cavity, haemangioma and arteriovenous malformation of the head of several children. |
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