| 2,4,6-三甲基苯乙酸的合成新方法 |
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| 引用本文： | 高莹,聂光辉,方旭兵,戴康.2,4,6-三甲基苯乙酸的合成新方法[J].精细化工中间体,2011,41(4):49-51. |
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| 作者姓名： | 高莹 聂光辉 方旭兵 戴康 |
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| 作者单位： | 中南民族大学药学院,湖北武汉,430074 |
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| 摘 要： | 以2,4,6-三甲基苯甲醛为原料,通过相转移催化反应在水-氯仿体系中先合成α-羟基-2,4,6-三甲基苯乙酸(收率52%);再通过次磷酸还原α-羟基-2,4,6-三甲基苯乙酸得到最终产物2,4,6-三甲基苯乙酸(收率91%)。此法绿色便捷,成本相对较低。
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| 关 键 词： | 2 4 6-三甲基苯乙酸 2 4 6-三甲基-α-羟基苯乙酸 相转移催化 |
Novel Method for the Preparation of Mesitylacetic Acid |
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| GA Ying,NIE Guang-hui,FANG Xu-bing,DAI Kang.Novel Method for the Preparation of Mesitylacetic Acid[J].Fine Chemical Intermediates,2011,41(4):49-51. |
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| Authors: | GA Ying NIE Guang-hui FANG Xu-bing DAI Kang |
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| Affiliation: | GAO Ying,NIE Guang-hui,FANG Xu-bing,DAI Kang*(Department of Pharmaceuticals,South-Central University For Nationalities,Wuhan 430074,China) |
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| Abstract: | A novel green and low-cost method for the synthesis of mesitylacetic acid from 2,4,6-trimethyl benzaldehyde via α-hydroxy mesitylacetic acid was presented.The process gave the product in an overall yield of 46%. |
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| Keywords: | mesitylacetic acid α-hydroxy mesitylacetic acid phase transfer catalysis |
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