| (R)4-羟基-2-氧代-1-吡咯烷基乙酰胺的合成 |
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| 引用本文： | 陈雪,雷英杰,丁玫,毕野.(R)4-羟基-2-氧代-1-吡咯烷基乙酰胺的合成[J].精细化工中间体,2011,41(5):21-23. |
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| 作者姓名： | 陈雪 雷英杰 丁玫 毕野 |
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| 作者单位： | 天津理工大学化学化工学院,天津,300384 |
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| 基金项目： | 天津市高等学校科技发展基金资助项目(20080509) |
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| 摘 要： | 以氯乙酰乙酸乙酯为原料,利用生物催化还原反应以及与甘氨酰胺的缩合反应,得到(R)4-羟基-2-氧代-1-吡咯烷基乙酰胺又称(R)-奥拉西坦],探讨了物料比、碱介质和温度对缩合反应的影响,其结构经比旋光度和1H NMR确证,总收率为52.7%。
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| 关 键 词： | (R)-奥拉西坦 生物催化还原 合成 |
Synthesis of(R) 4-Hydroxy-2-oxo-1-pyrrolidineacetamide |
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| CHEN Xue,LEI Ying-jie,DING Mei,RI Ye.Synthesis of(R) 4-Hydroxy-2-oxo-1-pyrrolidineacetamide[J].Fine Chemical Intermediates,2011,41(5):21-23. |
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| Authors: | CHEN Xue LEI Ying-jie DING Mei RI Ye |
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| Affiliation: | CHEN Xue,LEI Ying-jie,DING Mei,BI Ye(College of Chemistry & Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China) |
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| Abstract: | The asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to the title compound(i.e.(R)-oxyracetam)catalyzed by Saccharomyces cerevisiae and followed with the condensation of 2-amino-acetamide in alkaline solution was investigated.The target compound was obtained in 52.7% yield and confirmed by specific rotation and 1H NMR. |
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| Keywords: | (R)-oxyracetam bioreduction synthesis |
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