| 2-氨基喹啉-3-甲酸乙酯的合成工艺改进 |
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| 引用本文： | 曾志刚,骆焱平. 2-氨基喹啉-3-甲酸乙酯的合成工艺改进[J]. 精细化工中间体, 2011, 41(5): 24-26 |
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| 作者姓名： | 曾志刚 骆焱平 |
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| 作者单位： | 海南大学环境与植物保护学院,海南海口,570228 |
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| 基金项目： | 海南省教育厅项目(Hj2009-19) |
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| 摘 要： | 以铁粉作还原剂,冰醋酸为溶剂,回流条件下,2-氰基-3-(2-硝基苯基)-丙烯酸乙酯经还原-加成环合得到2-氨基喹啉-3-甲酸乙酯。实验优化原料比为n[2-氰基-3-(2-硝基苯基)-丙烯酸乙酯]∶n(铁粉)=1∶5。在此反应条件下,标题化合物经还原-加成环合后的收率达到94.7%,其结构经1H NMR和GC-MS表征确认。
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| 关 键 词： | 2-氨基喹啉-3-甲酸乙酯 合成 工艺 |
Process Improvement on the Synthesis of Ethyl 2-Aminoquinoline-3-carboxylate |
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| ZENG Zhi-gang,LUO Yan-ping. Process Improvement on the Synthesis of Ethyl 2-Aminoquinoline-3-carboxylate[J]. Fine Chemical Intermediates, 2011, 41(5): 24-26 |
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| Authors: | ZENG Zhi-gang LUO Yan-ping |
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| Affiliation: | ZENG Zhi-gang,LUO Yan-ping(College of Environment and Plant Protection of Hainan University,Haikou 570228,China) |
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| Abstract: | 2-Cyano-3-(2-nitrophenyl)-ethyl acrylate was converted to ethyl 2-aminoquinoline-3-carboxylate under reflux in acetic acid with iron powder as the reducing agent.The results showed that the optimum molar ratio of 2-cyano-3-(2-nitrophenyl)-ethyl acrylate to iron powder was 1 to 5,and the target compound was obtained in 94.7% yield with the structure confirmed by 1H NMR and GC-MS. |
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| Keywords: | 2-aminoquinoline-3-carboxylic acid ethyl ester synthesis process |
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