Poly (ADP-ribose) polymerase, a potential target for drugs: Part II. Regulation of differentiation by the poly ADP-ribose system |
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| Authors: | E Kun |
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| Affiliation: | London Centre for Paediatric Endocrinology at Great Ormond Street and The Middlesex Hospitals, UK. |
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| Abstract: | It is shown that eukaryotic differentiation is specifically sensitive to pADPRT regulation in Trypanosomna, Leishmania and Mytilus models. There is powerful inhibition of early differentiation without cell toxicity by pADPRT ligands. |
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