Polyvinylpolypyrrolidone-Supported Chlorosulfonic Acid: An Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones and Octahydroquinazolin-2,5-diones |
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Authors: | Masoumeh Goudarzvand Chegini Masoud Mokhtary |
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Affiliation: | Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran |
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Abstract: | Polyvinylpolypyrrolidone-supported chlorosulfonic acid has been successfully applied to perform one-pot reaction of arylaldehydes, urea, ethylacetoacetate, or cyclic 1,3-diketo compounds under solvent-free condition at 70°C to provide a series of dihydropyrimidinones and octahydroquinazolin-2,5-diones in good to excellent yields. The method offers several advantages such as high yield, short reaction time, simple workup, easy preparation, and reusability of the catalyst. The [PVPP-SO3H]+Cl? catalyst was characterized via Fourier transform infrared spectroscopy (FT-IR) and thermal gravimetric analysis (TGA). Moreover, the catalyst could be recycled several times without significant loss of its catalytic activity. Clean methodologies, easy work-up procedure, high yield, and simple preparation of the catalyst are some advantages of this article. |
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Keywords: | Chlorosulfonic acid dihydropyrimidinones octahydroquinazolin-2,5-diones polyvinylpolypyrrolidone solvent-free condition |
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