Transjugular intrahepatic portosystemic shunt: midterm clinical and angiographic follow-up |
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| Authors: | DJ Fillmore FJ Miller LF Fox JA Disario CC Tietze |
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| Affiliation: | SmithKline Beecham Pharmaceuticals, Harlow, Essex, U.K. |
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| Abstract: | The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation. |
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