| 双臂大环稀土配合物的合成及其生物活性 |
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| 引用本文： | 胡学雷,孟美娜,姜治平,张道霞,甘东东,曾令康,葛燕丽.双臂大环稀土配合物的合成及其生物活性[J].武汉工程大学学报,2014(4):12-16. |
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| 作者姓名： | 胡学雷 孟美娜 姜治平 张道霞 甘东东 曾令康 葛燕丽 |
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| 作者单位： | [1]武汉工程大学化工与制药学院,湖北武汉430074; [2]绿色化工过程教育部重点实验室(武汉工程大学),湖北武汉430074 |
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| 基金项目： | 湖北省自然科学基金重点项目（2011CDA048） |
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| 摘 要： | 为进一步发展新型Robson大环配合物体系,在三价铒离子的存在下,用2,6-二甲酰基-4-甲基苯酚和三(3-氨基丙基)胺(trpn)通过2+2]模板缩合反应直接合成了一个新型的双臂大环单核稀土铒配合物,通过物理方法对其进行了结构表征,用凝胶电泳实验和抗菌实验初步考察了配合物的生物活性.电喷雾质谱研究表明:配合物为2+2]缩合反应生成的单核结构.凝胶电泳实验研究表明:标题配合物能将DNA切割成环形缺刻型DNA,并以插入方式与相DNA结合;同时抑菌毒性实验证实了配合物对大肠杆菌也有一定的抑制作用.
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| 关 键 词： | 稀土 大环配体 切割DNA 抑菌 |
Synthesis and biological activities of new lanthanide complex with suspended-armed macrocyclic ligand |
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| Affiliation: | HU Xue-lei,MENG Mei-na,JIANG Zhi-ping,ZHANG Dao-xia,GAN Dong-dong,ZENG Ling-kang,GE Yan-li(1.School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430074, China;2.Key Laboratory for Green Chemical Process of Ministry of Education(Wuhan Institute of Technology),Wuhan 430074,China) |
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| Abstract: | To develop new Robson macrocyclic complexes,a new suspended-armed macrocyclic erbium complex was synthesized by 2＋2] condensation of 2,6-diformyl-4-methyl phenol and three （3-aminopropyl） amine （trpn） in the presence of erbium ion.The title complex was characterized by physical methods,and the biological activities of the complex were studied by agarose gel electrophoresis and antibacterial toxic experiment.The electrospray mass spectrum of the complex shows that the complex is a mononuclear complex which is derived from 2＋ 2] condensation reaction.The study of agarose gel electrophores shows that the complex can cleave the pBR322 DNA into an open circular relaxed form,and the complex binds to DNA mainly in an intercalating mode.The results of antibacterial toxic experiment show that the title complexes have inhibiting effects on escherichia coli. |
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| Keywords: | rare earth macrocyclic complex DNA cleavage inhibition of escherichia coli |
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