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Degradation Kinetics of Diltiazem |
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| Authors: | M. S. Suleiman M. E. Abdulhameed N. M. Najib H. Y. Muti |
| Affiliation: | a Departments of Pharmaceutical Technology and Research and Development Department, Dar ALDawa Development and Investement Co., Ltd., Na'ur,, Jordanb Medicinal Chemistry, Faculty of Pharmacy,, Jordan University of Science and Technology., Irbid, Jordan |
| Abstract: | The kinetics of degradation of diltiazem hydrochloride in aqueous buffered solutions (pH 1-7) were studied. Diltiazem was found to undergo hydrolysis to desacetyldiltiazem. The decomposition of diltiazem followed pseudo-first order kinetics under the experimental conditions. The drug was relatively stable over the pH range 3-6 with optimum stability at pH 5. The extrapolated shelf-life at this pH was 42.0 days compared to 15.8 day at pH 2. |
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