| 短双歧杆菌A04菌株体内抗氧化活性的初步研究 |
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| 引用本文： | 江志杰,高春,余立,李平兰. 短双歧杆菌A04菌株体内抗氧化活性的初步研究[J]. 食品科技, 2012, 0(10): 74-78,82 |
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| 作者姓名： | 江志杰 高春 余立 李平兰 |
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| 作者单位： | 中国农业大学食品科学与营养工程学院;北京市药品检验所 |
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| 摘 要： | 研究短双歧杆菌A04菌株和其菌体破碎物体内抗氧化和抗衰老作用的机理。利用D-半乳糖诱导法建立的小鼠亚急性衰老动物模型,分别给予短双歧杆菌A04菌株、菌体破碎物、Vc以及0.9%氯化钠溶液,观察血清中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活力、丙二醛(MDA)含量等的变化和对脑组织中脂褐质、单胺氧化酶(MAO)含量的影响以及肝脏组织中MDA含量和谷胱甘肽-s-转移酶(GST)活力的变化;通过观察小鼠脑组织和肝脏组织中蛋白质的合成能力以及免疫器官脾脏质量的变化,了解短双歧杆菌A04菌株和其菌体破碎物对其影响。短双歧杆菌A04菌株和其菌体破碎物能够提高血清中的SOD、CAT活力,降低血清、肝脏中的MDA的含量和脑组织中的脂褐质和MAO的含量以及增强肝脏和脑组织中蛋白质的合成能力,对D-半乳糖所致衰老引起的活性氧自由基损伤具有一定修复作用。短双歧杆菌A04菌株活菌和菌体破碎物改善衰老的作用与其抗氧化活性有关,其抗衰老机理不是单一途径实现的。
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| 关 键 词： | 短双歧杆菌 菌体破碎物 抗氧化 |
The antioxidant activity of B. breve A04 in vivo |
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| JIANG Zhi-jie,GAO Chun,YU Li,LI Ping-lan. The antioxidant activity of B. breve A04 in vivo[J]. Food Science and Technology, 2012, 0(10): 74-78,82 |
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| Authors: | JIANG Zhi-jie GAO Chun YU Li LI Ping-lan |
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| Affiliation: | 1* (1.College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083; 2.Beijing Institute of Drug Control, Beijing 100035) |
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| Abstract: | It was investigated that the antioxidant activity of Bifidobacterium breve A04 and intracellular cell-free extracts of B. breve A04 in vivo. The effects of B.breve A04 and intracellular cell-free extracts on the anti-aging in mice induced by D-galactose were determined by biochemistry method. B. breve A04 and intracellular cell-free extracts could repair the damages induced by aging, enhance the activities of SOD, CAT, reduce the content of MDA, lipofuscin and the activity of MAO. B.breve A04 and intracellular cell-free extracts could have anti-aging action with some action mechanisms. |
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| Keywords: | Bifidobacterium intracellular cell-free extracts antioxidation |
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