| 冷溶性琼脂多糖抗肿瘤作用的研究 |
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| 引用本文： | 孙新华,郑国强,滕安国,范维江,陈宏硕,刘安军.冷溶性琼脂多糖抗肿瘤作用的研究[J].食品科技,2012(6):220-224. |
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| 作者姓名： | 孙新华 郑国强 滕安国 范维江 陈宏硕 刘安军 |
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| 作者单位： | 天津科技大学食品工程与生物技术学院;河北联合大学电气工程学院 |
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| 基金项目： | 科技部科技型中小企业技术创新基金(10C26211200196);国家自然科学基金(31000755);天津科技大学校基金(20090208) |
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| 摘 要： | 以琼脂中的冷溶性琼脂多糖为研究对象,探讨其体内抗肿瘤作用及机理。10～15℃下水浸提琼脂中的多糖,并对其进行了组分分析。小鼠腋下接种H22肝癌细胞建立动物模型,以1000mg/kg·d灌胃给药。通过瘤重、抑瘤率、脏器指数、免疫器官切片HE染色、脾细胞增殖能力、NK细胞杀伤活性测定、吞噬细胞吞噬能力测定等研究其抗肿瘤作用和机理。测得其总糖含量为76.74%,抑瘤率为77.81%,小鼠免疫系统得到保护,增强了抗肿瘤作用。冷溶性琼脂多糖有显著的抗肿瘤作用,在保护免疫系统,提高免疫力方面有很好的作用。
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| 关 键 词： | 琼脂多糖 抗肿瘤 免疫调节 |
Antitumor effects of low temperature dissolved agar polysaccharide on mice |
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| SUN Xin-hua,ZHENG Guo-qiang,TENG An-guo,FAN Wei-jiang,CHEN Hong-shuo,LIU An-jun.Antitumor effects of low temperature dissolved agar polysaccharide on mice[J].Food Science and Technology,2012(6):220-224. |
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| Authors: | SUN Xin-hua ZHENG Guo-qiang TENG An-guo FAN Wei-jiang CHEN Hong-shuo LIU An-jun |
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| Affiliation: | 1*(1.College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300457;2.Electrical Engineering,Hebei United University,Tangshan 063009) |
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| Abstract: | To study the antitumor activity in vivo of low temperature dissolved agar polysaccharide.Low temperature dissolved agar polysaccharide was extracted with water from agar at 10～15 ℃.The isolate was analyzed that it contained 76.74% polysaccharide.H22 tumor bearing mice were established and treated by gavage with 1000 mg/kg of the polysaccharide.The tumor weight,tumor inhibition rate,thymus index,HE staining of thymus,lymphocyte proliferation,kill rate of NK cells,detection of phagocytic were measured to study antitumor function in vivo.The low temperature dissolved agar polysaccharide had definite antitumor effect and the tumor inhibition rate is 77.81%.It could protect the immune system and promote the immune function of tumor bearing mice. |
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| Keywords: | agar polysaccharide antitumor immunity regulation |
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