| MgSO4对大鼠急性放射性脑损伤后脑细胞内Ca2+及脑组织NO含量的影响 |
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| 引用本文： | 袁文佳,崔凤梅,王利利,刘萍,何超,涂彧. MgSO4对大鼠急性放射性脑损伤后脑细胞内Ca2+及脑组织NO含量的影响[J]. 辐射研究与辐射工艺学报, 2009, 27(1) |
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| 作者姓名： | 袁文佳 崔凤梅 王利利 刘萍 何超 涂彧 |
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| 作者单位： | 苏州大学医学部放射医学与公共卫生学院,苏州,215123;苏州大学附属第一医院肿瘤放疗科,苏州,215006 |
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| 摘 要： | 为探讨硫酸镁(MgSO4)对电离辐射诱发脑损伤的保护作用,将成熟的SD大鼠36只随机分为空白对照组、实验对照组和硫酸镁实验用药组,用6 MeV电子束对实验组大鼠进行20 Gy全脑单次垂直照射,吸收剂量率为200 cGy/min;实验用药组大鼠于照射前1 d、照射后即刻和照射后连续5 d分别给予10%的MgSO4腹腔注射,分别于照后第3、10、17和24 d解剖大鼠,取其脑组织,用激光扫描共聚焦显微镜测定脑细胞内ca2+的含量,硝酸还原酶法测定脑组织一氧化氮(NO)含量.结果显示,与空白对照组相比,实验对照组大鼠脑细胞内Ca2+平均荧光强度及脑组织中NO含量明显升高(P＜0.05);与实验对照组相比,实验用药组大鼠脑细胞内Ca2+平均荧光强度及脑组织NO含量有所降低(P＜0.05).表明早期使用硫酸镁可抑制辐射引起的脑细胞内钙离子的超载及脑组织中NO含量的升高,硫酸镁对放射性脑损伤有保护作用.
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| 关 键 词： | 放射性脑损伤 硫酸镁 细胞内钙离子 一氧化氮 |
Effect of MgSO_4 on the contents of Ca~(2+) in brain cell and NO in brain tissue of rats with radiation-induced acute brain injury |
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| YUAN Wenjia,CUI Fengmei,WANG Lili,LIU Ping,HE Chao,TU Yu. Effect of MgSO_4 on the contents of Ca~(2+) in brain cell and NO in brain tissue of rats with radiation-induced acute brain injury[J]. Journal of Radiation Research and Radiation Processing, 2009, 27(1) |
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| Authors: | YUAN Wenjia CUI Fengmei WANG Lili LIU Ping HE Chao TU Yu |
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| Affiliation: | School of Radiation Medicine and Public Health;Suzhou University;Suzhou 215123;China;Department of Radiation Oncology;the First Affiliated Hospital to Suzhou University;Suzhou 215006;China |
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| Abstract: | The work is to explore the protection of magnesium sulfate(MgSO4) on radiation-induced acute brain injury. Thirty six mature Sprague-Dawley(SD) rats were randomly divided into 3 groups of control, experimental control and experimental therapy group. The whole brains of SD rats of experimental control and experimental therapy group were irradiated with a dose of 20 Gy using 6 MeV electron beam. MgSO4 was injected into the abdomen of experimental therapy rats group 1day before, immediately and continue for 5d... |
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| Keywords: | Radiation-induced brain injury Magnesium sulfate Intracellular free calcium NO |
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