| 联苯苄唑阴道片豚鼠血药浓度及吸收率测试 |
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| 引用本文： | 付良青,骆传环.联苯苄唑阴道片豚鼠血药浓度及吸收率测试[J].质谱学报,1999,20(2):43-48. |
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| 作者姓名： | 付良青 骆传环 |
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| 作者单位： | 军事医学科学院附属医院!北京100039(付良青，骆传环，舒融)，军事医学科学院放射医学研究所!北京100850(王恩起，金文涛，周昭武) |
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| 摘 要： | 本文采用ＧＣ／ＭＳ单离子检测的内标定量法，测定了抗真菌药联苯苄唑阴道片三种剂量６．２５ｍ ｇ，１２．５ｍ ｇ，２５ｍ ｇ 在给豚鼠连续用药２１天后豚鼠血药浓度，分别为１６．３ｎｇ／ｍ ｌ，２３．５ｎｇ／ｍ ｌ，２７．６ｎｇ／ｍ ｌ；并计算三种剂量的粘膜吸收百分率，结果分别为０．１０４３％ ，０．０７５２％ ，０．０４４２％ 。
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| 关 键 词： | 联苯苄唑 GC/MS 吸收率 |
Concentration and Absorption Percentage Determination of Bifonazole Table for Vagina in Cavy |
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| Abstract: | Using GC/MS SIM quantitative method with ISTD,we determinated the Bifonazole concentration in cavy's plasma,the administration doses were 6.25mg,12.5mg,25.0mg respectively;and calculated the mucous membrane absorption percentage.The results showed the concentrations of bifonazole in plasma were 16.3,23.5,27.6 ng/ml for three doses,and their absorption percent age are 0 1043,0.0752,0.0442%,respectively. |
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| Keywords: | bifonazole GC/MS absorption percentage |
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