| 2,5-二甲基-4-羟基-3(2H)-呋喃酮的合成研究 |
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| 引用本文： | 张精安.2,5-二甲基-4-羟基-3(2H)-呋喃酮的合成研究[J].精细化工,2001,18(1):31-33. |
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| 作者姓名： | 张精安 |
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| 作者单位： | 广东药学院"药学系, |
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| 摘 要： | 以丙酮醛为原料 ,用锌粉作偶联剂 ,加入适量的氯化锂和碘化四丁基铵 ,n(CH3COCHO)∶n(Zn)∶n(HOAc) =1 0∶1 0∶1 5 ,在 2 5℃反应 1 5～ 2 0h ,可得产率为 6 1 5 %的 2 ,5 二羟基 3,4 己二酮 ;用磷酸氢二钠作缩合剂 ,用超声波加热回流 12h ,可得产率为 6 8 2 %的标题化合物 ;二步的总产率为 41 9%。
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| 关 键 词： | 2 5-二甲基-4-羟基3(2H)-呋喃酮 食品增香剂 丙酮醛 |
| 文章编号： | 1003-5214(2001)01-0031-03 |
| 修稿时间： | 2000年9月3日 |
Synthesis of 2,5-Dimethyl-4-hydroxy-3(2H) furanone |
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| ZHANG Jing-an.Synthesis of 2,5-Dimethyl-4-hydroxy-3(2H) furanone[J].Fine Chemicals,2001,18(1):31-33. |
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| Authors: | ZHANG Jing-an |
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| Abstract: | 2,5-Dihydroxy-3,4-hexanedione(Ⅰ) was prepared from pyruvaldehyde with zinc powder as coupling agent and lithium chloride and tetrabutylammonium iodide as catalysts.At n(CH3COCHO)∶n(Zn)∶n(HOAc)=1.0∶1.0∶1.5,the yield of Ⅰ was 61.5%. The title compound (Ⅱ) was synthesized from Ⅰ with disodium hydrogen phosphate as condensation agent.After being refluxed for 12 h with ultrasonic wave,the yield of Ⅱ was 68.2%.Total yield of two steps was 41.9%. |
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| Keywords: | dimethyl 4 hydroxy 3(2H) furanone food flavour enhancer pyruvaldehyd |
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