| Paal-Knorr缩合法合成N-烷氧羰基-2,5-二甲基吡咯 |
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| 引用本文： | 张娟,范晓东,刘毅锋,李华. Paal-Knorr缩合法合成N-烷氧羰基-2,5-二甲基吡咯[J]. 现代化工, 2006, 26(11): 47-49 |
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| 作者姓名： | 张娟 范晓东 刘毅锋 李华 |
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| 作者单位： | 1. 西北工业大学化工系,陕西,西安,710072
2. 西北大学应用化学研究所,陕西,西安,710069 |
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| 摘 要： | 用对甲苯磺酸作催化剂、甲苯为溶剂,使氨基甲酸酯和2,5-己二酮进行Paal-Knorr缩合反应,共沸脱水6 h,合成出了5种N-烷氧羰基-2,5-二甲基吡咯,产率为76%~89%。探讨了氨基甲酸酯和2,5-己二酮进行Paal-Knorr缩合反应的机理,研究了催化剂种类及用量、反应溶剂和氨基甲酸酯的结构对缩合反应产率的影响。
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| 关 键 词： | 氨基甲酸酯 2,5-己二酮 Paal-Knorr缩合 N-烷氧羰基-2,5-二甲基吡咯 |
| 文章编号： | 0253-4320(2006)11-0047-03 |
| 修稿时间： | 2006-07-24 |
Synthesis of N-carboalkyloxy-2,5-dimethylpyrroles by the Paal-Knorr condensation of carbamate with diketone |
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| ZHANG Juan,FAN Xiao-dong,LIU Yi-feng,LI Hua. Synthesis of N-carboalkyloxy-2,5-dimethylpyrroles by the Paal-Knorr condensation of carbamate with diketone[J]. Modern Chemical Industry, 2006, 26(11): 47-49 |
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| Authors: | ZHANG Juan FAN Xiao-dong LIU Yi-feng LI Hua |
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| Abstract: | Five N-carboalkyloxy-2,5-dimethylpyrroles were synthesized by Paal-Knorr condensation from carbamate and 2,5-hexanedione in toluene at the reflux temperature for 6 h.The yields of the condensation reaction were 76%-89%.The mechanism of Paal-Knorr reaction between a carbamate and 2,5-hexanedione to form a pyrrole was explored.The influences of category and dose of catalysts,solvents and the structure of carbamates on the yields of the condensation reaction were also studied. |
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| Keywords: | carbamates 2 5-hexanedione Paal-Knorr condensation N-carboalkyloxy-2 5-dimethylpyrrole |
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