Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration |
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| Authors: | AM Sullivan J Opacka-Juffry J Pohl SB Blunt |
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| Affiliation: | Department of Neurodegenerative Disorders and MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. a.sullivan@uc.ie |
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| Abstract: | Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway from 6-hydroxydopamine-induced damage. Here we used amphetamine-induced rotational testing, high-performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. We also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites). |
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