| 液相色谱-串联质谱法测定人血浆中克拉霉素的浓度 |
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| 引用本文： | 权伍英,于晓英,王 璟,栾 燕. 液相色谱-串联质谱法测定人血浆中克拉霉素的浓度[J]. 质谱学报, 2006, 27(Z1): 109-110 |
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| 作者姓名： | 权伍英 于晓英 王 璟 栾 燕 |
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| 作者单位： | 沈阳市疾病预防控制中心，辽宁 沈阳 110031 |
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| 摘 要： |
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Determination of Clarithromycin in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry |
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| QUAN Wu-ying,YU Xiao-ying,WANG Jing,LUAN Yan. Determination of Clarithromycin in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry[J]. Journal of Chinese Mass Spectrometry Society, 2006, 27(Z1): 109-110 |
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| Authors: | QUAN Wu-ying YU Xiao-ying WANG Jing LUAN Yan |
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| Affiliation: | Shenyang Center for Disease Control & Prevention, Shenyang 110031, China |
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| Abstract: | A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to determine clarithromycin in human plasma. The linearity was obtained in the range of 10~5 000 ng/mL in plasma and the limit of quantification was 10 ng/mL. The intra and inter-day precision (RSD) were less than 2.9% and 9.2%, respectively. Accuracy(relative error)was with in 3.2%. The method was proved to be convenient, rapid and accurate enough to be applied to the pharmacokinetic studies of clarithromycin in human plasma. |
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| Keywords: | clarithromycin LC-MS/MS plasmaconcentration |
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