植物多酚通过MAPK信号通路调控肿瘤作用机制研究进展

肿瘤细胞的生物学过程(增殖、分化、侵袭、迁移)是癌症发生的标志,丝裂原活化蛋白激酶(mitogenactivated protein kinase,MAPK)被证实是调节肿瘤细胞生物学过程的至关重要的信号通路。大量研究表明,天然植物多酚,如茶多酚、白藜芦醇、花青素等对肿瘤细胞有显著的调节作用,植物多酚介导的MAPK通路对肿瘤细胞的调节已经引起国内外学者的广泛兴趣。文章综述了植物多酚通过MAPK信号通路对肿瘤细胞的调控作用,分析了不同多酚对MAPK信号通路的4条途径(p38、ERK-1/2、ERK5、JNK)的响应机制,旨在为明确植物多酚的抗肿瘤活性及分子机制、开发抗肿瘤保健食品或药物提供参考。

Plant Polyphenols Exert Antitumor Effect through MAPK Signaling Pathways: A Review

The biological processes of tumor cells such as proliferation, differentiation, invasion and migration are the signs of cancer. The mitogen-activated protein kinase (MAPK) signaling pathway has been proved to be an essential pathway that can adjust the biological processes of tumor cells. A number of studies indicate that natural plant polyphenols, such as tea polyphenols, resveratrol and anthocyanins, have a significant regulatory effect on tumor cells. Plant polyphenols can adjust tumor cells through the MAPK signaling pathway, which has attracted widespread research interest worldwide. This article reviews the regulating effect of plant polyphenols on tumor cells through the MAPK signaling pathway and elucidates the response mechanisms of different polyphenols to the four MAPK signaling pathways (p38, ERK-1/2, ERK5 and JNK pathways), aiming to further clarify the antitumor activity of plant polyphenols and the underlying molecular mechanisms and provide a reference for developing anticancer health foods or drugs.