吉林人参低聚肽对高脂血症大鼠的影响

目的:观察吉林人参低聚肽(ginseng oligopeptides,GOP)对高脂血症模型大鼠是否具有降脂作用。方法:取SD大鼠108只,设立9个实验组:6个GOP剂量组(0.062 5、0.125 0、0.250 0、0.500 0、1.000 0、2.000 0 g/kg)、1个空白对照组、1个乳清蛋白组(0.250 0 g/kg)和1个模型对照组。空白对照组每日给予基础饲料,其余各组每日给予高脂饲料,2周后各组继续给予相应饲料并连续灌胃30 d。结果:GOP各剂量组大鼠血清胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯含量均无明显变化(P0.05);GOP能够降低高脂血症大鼠血清和肝脏丙二醛含量(P0.01),提高血清和肝脏超氧化物歧化酶、谷胱甘肽过氧化物酶活力(P0.01),升高血清一氧化氮和一氧化氮合酶含量(P0.01)。结论:GOP没有辅助降血脂作用,GOP可能具有抗动脉硬化作用。

Hypolipidemic Effect of Oligopeptide Derived from Panax ginseng Grown in Jilin Province on Rats with Hyperlipidemia

Purpose: To investigate the effect of oligopeptide from Panax ginseng grown in Jilin province (GOP) on hyperlipidemic rats. Methods: Totally 108 specific pathogen free (SPF) male SD rats were randomly divided into 9 groups: normal control, model, whey protein group, and six GOP groups with different doses. The rats from the normal control group were fed a basal diet only. The rats from the rest groups were fed a high-fat diet for 2 weeks. Then, the rats in six GOP groups were gavaged with GOP at doses of 0.062 5, 0.125 0, 0.250 0, 0.500 0, 1.000 0 and 2.000 0 g/kg, respectively, those in the normal control and model groups with the same volume of distilled water, and those in the whey protein group with whey protein at a dose of 0.250 0 g/kg for 30 days. At the same time, all rats were provided with the corresponding diets uninterruptedly. Results: The TC, LDL-C, HDL-C and TG levels in serum had no significant change in rats from the GOP groups at each dose. The MDA level was significantly decreased and SOD and GSH-Px activities were significantly elevated in serum and liver tissue of rats from the GOP groups. Besides, serum NO and NOS levels were significantly elevated in the GOP groups. Conclusion: GOP does not has a hypolipidemic effect, but it may have an anti-atherosclerosis effect.