刺玫籽油及原花青素降血脂作用

通过动物实验对刺玫籽油和刺玫籽原花青素进行降血脂功能性研究。选用昆明雄性小鼠,通过高脂饲料饲喂建立高脂模型小鼠,分别经口灌胃刺玫籽油及原花青素5周后,检测分析小鼠血清及肝组织匀浆各项指标。结果显示,刺玫籽油及原花青素对小鼠体质量及主要脏器指数无显著影响;中剂量(100 mg/kg)、高剂量(200 mg/kg)的刺玫籽原花青素会显著降低高脂小鼠血清内低密度脂蛋白胆固醇、总胆固醇、甘油三酯含量(P0.05),显著升高小鼠肝组织内超氧化物歧化酶活力、过氧化氢酶活力、谷胱甘肽过氧化酶水平(P0.05),显著降低肝组织内丙二醛水平;低剂量(80 mg/kg)刺玫籽油能显著降低高脂小鼠血清内甘油三酯水平(P0.05)及显著升高小鼠肝组织中过氧化氢酶活力(P0.05)。研究结果表明,低剂量的刺玫籽油和中、高剂量的刺玫籽原花青素对高脂血症小鼠有一定的降血脂作用。

Hypolipidemic Activity of Seed Oil and Procyanidins of Rosa davurica Pall.

The hypolipidemic activity of the seed oil and procyanidins of Rosa davurica Pall. was investigated by animal tests. Kunming male mice fed a high fat diet were used as a hyperlipidemic animal model. After oral administration for 5 weeks, serum and liver homogenate were collected for the measurement of parameters of interest. Compared with the hyperlipidemic model group, both drugs had no significant effect on body weight and visceral organ indexes in mice. The proanthocyanidins at middle (100 mg/kg) and high doses (200 mg/kg) could significantly reduce serum LDL-C, TC and TG (P < 0.05), significantly improve liver superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels (P < 0.05), and significantly decrease liver MDA level. The oil at low dose (80 mg/kg) could evidently reduce serum TG levels in hyperlipidemic mice (P < 0.05) and significantly increase in liver CAT activity (P < 0.05). Therefore, the seed oil at low dose and the procyanidins at middle and high doses play a role in reducing blood lipids in hyperlipidemic mice.