| 医药中间体溴代环丙烷合成新工艺的研究 |
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| 引用本文： | 张文楠,崔惠芳等. 医药中间体溴代环丙烷合成新工艺的研究[J]. 广州化工, 2000, 28(4): 106-107 |
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| 作者姓名： | 张文楠 崔惠芳等 |
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| 作者单位： | 河南省科学院化学研究所!郑州450002 |
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| 摘 要： | 以γ-丁内酯为起始原料,通过改变工艺条件和选用相转移催化剂使新工艺三步即合成出医药中间体溴代环丙烷,与原五步法合成工艺相比,不但缩短了工艺流程,易于工业化生产,而且使总收率由32%提高到45%。
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| 关 键 词： | γ－丁内酯 溴代环丙烷 相转移催化剂 药物中间体 |
A New Synthetic Technique of Bromocy Clopropane |
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| Zhany Wennan,Li Tianxuan,Chi Huifang Zhu Jing. A New Synthetic Technique of Bromocy Clopropane[J]. GuangZhou Chemical Industry and Technology, 2000, 28(4): 106-107 |
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| Authors: | Zhany Wennan Li Tianxuan Chi Huifang Zhu Jing |
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| Abstract: | Using r - butyrolactone as the raw material, by selecting the optimum technical conditions and a phase transfer catalyst, The whole work was made up of three steps to synthesize bromocyclopropane. The overall yield was up from 35% to 45%. The reaction was easier to control and the cost was lower. This new method is more suitable for the industrial production. |
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| Keywords: | r- butyrolactone bromocyclopropane phase transfer catalyst |
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