| 抗抑郁药西酞普兰双键杂质的合成 |
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| 引用本文： | 俞灵军,张仲飞,陈李荔,张道振.抗抑郁药西酞普兰双键杂质的合成[J].广州化工,2010,38(8):180-181. |
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| 作者姓名： | 俞灵军 张仲飞 陈李荔 张道振 |
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| 作者单位： | 1. 浙江大学材化学院,浙江,杭州,310027
2. 浙江天蓝环保技术有限公司,浙江,杭州,311202 |
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| 摘 要： | 4-1-(4-二甲胺基)-1-(4-氟苯基)-丁烯基]-3-(羟甲基)-苯腈是抗抑郁药西酞普兰合成中的一个副产物,对研究西酞普兰成品的质量具有较大价值。本文以4-4-(二甲胺基)-1-(4-氟苯基)-羟基丁基]-3-(羟甲基)-苯腈为起始原料,依次用特戊酰氯酰化,对甲苯磺酸脱水,最后用NaOH溶液催化水解特戊酰基,用甲苯重结晶后得到纯度在99%以上的4-1-(4-二甲胺基)-1-(4-氟苯基)-丁烯基]-3-(羟甲基)-苯腈成品,合收率约49%。
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| 关 键 词： | 西酞普兰 酰化 脱水 水解 |
Synthesis of the Impurity of Antidepressant Citalopram |
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| YU Ling-jun,ZHANG Zhong-fei,CHEN Li-li,ZHANG Dao-zhen.Synthesis of the Impurity of Antidepressant Citalopram[J].GuangZhou Chemical Industry and Technology,2010,38(8):180-181. |
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| Authors: | YU Ling-jun ZHANG Zhong-fei CHEN Li-li ZHANG Dao-zhen |
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| Affiliation: | 1 College of Chemistry,Zhejiang University,Zhejiang Hangzhou 310027;2 Zhejiang Tianlan Environmental Protection Technology Co.,Ltd.,Zhejiang Hangzhou 311202,China) |
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| Abstract: | 4-1-（4-dimethylamino）-1-（4-fluorophenyl） butenyl]-3-（hydroxymethyl） benzonitrile was a by-product when producing the antidepressant citalopram.It had a great value to studying the quality of citalopram.In order to synthesize it,4-4-（dimethylamino）-1-（4-fluorophenyl）-hydroxy-butyl]3-（hydroxymethyl）-benzonitrile used as the starting material,acylated by 2,2-dimethylpropanoyl chloride,then dehydrated by TSCL,hydrolyzed by the catalyst of NaOH solution,and finally recrystallization with toluene in order to get the purity of the product more than 99%.The total yield of this synthetic route can get to 49%. |
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| Keywords: | citalopram acylate dehydrate hydrolyze |
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