Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins |
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| Authors: | T Tanami K Kameo N Ono T Nakagawa S Annou M Tsuboi K Tani S Okamoto F Sato |
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| Affiliation: | Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan. |
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| Abstract: | 13-Dehydro derivatives of prostaglandin E1, E2, E3, F1 alpha and F2 alpha were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum. |
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