Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain |
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| Authors: | TA Gudasheva SS Boyko VKh Akparov RU Ostrovskaya SP Skoldinov GG Rozantsev TA Voronina VP Zherdev SB Seredenin |
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| Affiliation: | Institute of Pharmacology, Russian Academy of Medical Science, Moscow, Russian Federation. |
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| Abstract: | Using high-performance liquid chromatography, gas-chromatography and chromato-mass spectrometry methods a novel endogenous cyclic dipeptide cyclo-prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 +/- 0.3 nmol/g wet brain. Synthetic cyclo-prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo-prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation. |
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